|
Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,〔Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. ''Journal of Medicinal Chemistry''. 2005; 48:1336-1343.〕 so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. == See also == * Moramide intermediate * Methadone intermediate * Pethidine intermediate B (norpethidine) * Pethidine intermediate C (pethidinic acid) 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Pethidine intermediate A」の詳細全文を読む スポンサード リンク
|